作者
Katarzyna Anna Dudek, Sam EJ Paton, Adeline Collignon, Manon Lebel, Olivier Lavoie, Jonathan Bouchard, Fernanda Neutzling Kaufmann, Laurence Dion-Albert, Valerie Clavet-Fournier, Luisa B Binder, Claudia Manca, Nicolas Flamand, Manuel Guzman, Matthew Campbell, Gustavo Turecki, Naguib Mechawar, Flavie Lavoie-Cardinal, Cristoforo Silvestri, Vincenzo Di Marzo, Caroline Menard
发表日期
2024/5/15
期刊
Biological Psychiatry
卷号
95
期号
10
页码范围
S2
出版商
Elsevier
简介
Background
Sex-specific blood-brain barrier (BBB) alterations contribute to stress vulnerability and development of depressive behaviors. Conversely, neurovascular adaptations underlying stress resilience remain unexplored. The endocannabinoid system (ECS) can regulate stress responses and BBB permeability thus, here we evaluate if it could be involved in stress-induced vascular changes.
Methods
Impact of chronic social stress on ECS-related gene expression was measured in male and female C57Bl/6 nucleus accumbens (NAc) and prefrontal cortex (PFC). Cell-specific changes were confirmed with RNA scope, and immunofluorescence in mouse and human samples. Viral-mediated manipulations were performed to confirm causality of altered astrocytic cannabinoid receptor (Cnr1) in establishment of anxiety-and depression-like behaviors at baseline and after stress.
Results
After stress exposure, Cnr1 …
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KA Dudek, SEJ Paton, A Collignon, M Lebel, O Lavoie… - Biological Psychiatry, 2024