作者
Roberto Armstrong-Jr, Fernanda Yamamoto Ricardo-da-Silva, Marina Vidal-dos-Santos, Cristiano de Jesus Correia, Lucas Ferreira Anunciação, Raphael dos Santos Coutinho e Silva, Luiz Felipe Pinho Moreira, Henri Gerrit Derk Leuvenink, Ana Cristina Breithaupt-Faloppa
发表日期
2021/7
期刊
Annals of translational medicine
卷号
9
期号
14
出版商
AME Publications
简介
Background
Clinical and experimental data highlight the consequences of brain death on the quality of organs and demonstrate the importance of donor state to the results of transplantation. Female rats show higher cardio-pulmonary injury linked to decreased concentrations of female sex hormones after brain-dead (BD). This study evaluated the effect of 17β-estradiol on brain death induced renal injury in female rats.
Methods
Female Wistar rats were randomically allocated into 4 groups: false-operation (Sham), BD, treatment with 17β-estradiol (50 µg/mL, 2 mL/h) 3 h after brain death (E2-T3), or immediately after brain death confirmation (E2-T0). Creatinine, urea, cytokines, and complement system components were quantified. Renal injury markers, such as KIM-1, Caspase-3, BCL-2 and MMP2/9 were evaluated.
Results
Brain death leads to increased kidney KIM-1 expression and longer 17β-estradiol treatment …
学术搜索中的文章
R Armstrong-Jr, FY Ricardo-da-Silva… - Annals of translational medicine, 2021