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The main challenge in today’s world to the healthcare system is the elevated occurrence of the neurodegenerative disorders. Progress in the field of bioinformatics and biomedical research has allowed us to understand the pathobiology of the neurodegenerative disorders in a detailed manner. The threat of these diseases increases with aging, and Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are the major ones affecting the public health and posing the higher economic burden. The research centers, pharmaceutical companies, and academic institutions are conducting research work in collaborations these days to enhance the development of new therapeutic strategies and develop novel drugs in a sustainable way. This can help in the development of safer therapies with reduced risk and can help in developing the authentic and evident biomarkers so …