作者
Aaina Singh Rathore, Hareram Birla, Saumitra Sen Singh, Walia Zahra, Hagera Dilnashin, Richa Singh, Priyanka Kumari Keshri, Surya Pratap Singh
发表日期
2021/7
来源
Neurochemical Research
卷号
46
期号
7
页码范围
1618-1626
出版商
Springer US
简介
In the recent past, huge emphasis has been given to the epigenetic alterations of the genes responsible for the cause of neurological disorders. Earlier, the scientists believed somatic changes and modifications in the genetic makeup of DNA to be the main cause of the neurodegenerative diseases. With the increase in understanding of the neural network and associated diseases, it was observed that alterations in the gene expression were not always originated by the change in the genetic sequence. For this reason, extensive research has been conducted to understand the role of epigenetics in the pathophysiology of several neurological disorders including Alzheimer’s disease, Parkinson’s disease and, Huntington’s disease. In a healthy person, the epigenetic modifications play a crucial role in maintaining the homeostasis of a cell by either up-regulating or down-regulating the genes. Therefore, improved …
引用总数
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AS Rathore, H Birla, SS Singh, W Zahra, H Dilnashin… - Neurochemical Research, 2021