作者
Arne Müller, Robert M MacCallum, Michael JE Sternberg
发表日期
2002/11/1
期刊
Genome research
卷号
12
期号
11
页码范围
1625-1641
出版商
Cold Spring Harbor Lab
简介
This paper reports an analysis of the encoded proteins (the proteome) of the genomes of human, fly, worm, yeast, and representatives of bacteria and archaea in terms of the three-dimensional structures of their globular domains together with a general sequence-based study. We show that 39% of the human proteome can be assigned to known structures. We estimate that for 77% of the proteome, there is some functional annotation, but only 26% of the proteome can be assigned to standard sequence motifs that characterize function. Of the human protein sequences, 13% are transmembrane proteins, but only 3% of the residues in the proteome form membrane-spanning regions. There are substantial differences in the composition of globular domains of transmembrane proteins between the proteomes we have analyzed. Commonly occurring structural superfamilies are identified within the proteome. The …
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A Müller, RM MacCallum, MJE Sternberg - Genome research, 2002