作者
Juan M Vargas-Morales, Rocio Guizar-Heredia, Ana L Méndez-García, Berenice Palacios-Gonzalez, Alejandro Schcolnik-Cabrera, Omar Granados, Adriana M López-Barradas, Natalia Vázquez-Manjarrez, Isabel Medina-Vera, Miriam Aguilar-López, Claudia Tovar-Palacio, Guillermo Ordaz-Nava, Ana K Rocha-Viggiano, Eduardo Medina-Cerda, Nimbe Torres, José M Ordovas, Armando R Tovar, Martha Guevara-Cruz, Lilia G Noriega
发表日期
2021/10/28
期刊
Nutrition, Metabolism and Cardiovascular Diseases
卷号
31
期号
11
页码范围
3210-3218
出版商
Elsevier
简介
Background and aim
Circulating amino acids are modified by sex, body mass index (BMI) and insulin resistance (IR). However, whether the presence of genetic variants in branched-chain amino acid (BCAA) catabolic enzymes modifies circulating amino acids is still unknown. Thus, we determined the frequency of two genetic variants, one in the branched-chain aminotransferase 2 (BCAT2) gene (rs11548193), and one in the branched-chain ketoacid dehydrogenase (BCKDH) gene (rs45500792), and elucidated their impact on circulating amino acid levels together with clinical, anthropometric and biochemical parameters.
Methods and results
We performed a cross-sectional comparative study in which we recruited 1612 young adults (749 women and 863 men) aged 19.7 ± 2.1 years and with a BMI of 24.9 ± 4.7 kg/m2. Participants underwent clinical evaluation and provided blood samples for DNA extraction and …
学术搜索中的文章
JM Vargas-Morales, R Guizar-Heredia… - Nutrition, Metabolism and Cardiovascular Diseases, 2021