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To determine the significance of the immunophenotypic heterogeneity of B‐cell chronic lymphocytic leukaemia (CLL), surface immunoglobulins (SIgs), mouse rosette assays (MR), and a panel of monoclonal antibodies for B cells, T cells and myeloid cells were performed on peripheral blood samples from 61 newly diagnosed cases. Four groups were observed: group I (SIg+, MR+, CD19/20+, CD5+, T antigen (Ag)‐; 27 cases); group II (SIg+, MR+, CD19/20+, CD5+, T Ag+; 17 cases); group III (SIg+, MR+ CD19/20+, CD5‐, T AG‐; 12 cases); and group IV (SIg‐, MR+, CD19/20+, Cd5+, T Ag‐; 5 cases). Groups were compared according to French–American–British Cooperative Group subtypes, clinical and laboratory features, Rai staging, and survival. Typical CLL morphology (>90% small lymphocytes) was present in 20/20 (100%) of group I cases and 23/27 (85%) group II, III and IV cases (P=0·09). Expression of a …