作者
Shukkur Muhammed Farooq, Abdul Shukkur Ebrahim, Karthik Harve Subramhanya, Ramasamy Sakthivel, Nachiappa Ganesh Rajesh, Palaninathan Varalakshmi
发表日期
2006/3/1
期刊
Molecular and cellular biochemistry
卷号
284
期号
1
页码范围
95-101
出版商
Springer Netherlands
简介
The assumption of oxidative stress as a mechanism in oxalate induced renal damage suggests that antioxidants might play a beneficial role against oxalate toxicity. An in vivo model was used to investigate the effect of C-phycocyanin (from aquatic micro algae; Spirulina spp.), a known antioxidant, against calcium oxalate urolithiasis. Hyperoxaluria was induced in two of the 4 groups of Wistar albino rats (n = 6 in each) by intraperitoneally injecting sodium oxalate (70,mg/kg body weight). A pretreatment of phycocyanin (100,mg/kg body weight) as a single oral dosage was given, one hour prior to oxalate challenge. An untreated control and drug control (phycocyanin alone) were employed. Phycocyanin administration resulted in a significant improvement (p < 0.001) in the thiol content of renal tissue and RBC lysate via increasing glutathione and reducing malondialdehyde levels in the plasma of oxalate …
引用总数
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Oxalate mediated nephronal impairment and its inhibition by c-phycocyanin: a study on urolithic rats
SM Farooq, AS Ebrahim, KH Subramhanya… - Molecular and cellular biochemistry, 2006