作者
Rehan Akbani, KadiráC Akdemir, B áArman Aksoy, Monique Albert, Adrian Ally, SamirkumaráB Amin, Harindra Arachchi, Arshi Arora, J áTodd Auman, Brenda Ayala, Julien Baboud, Miruna Balasundaram, Saianand Balu, Nandita Barnabas, John Bartlett, Pam Bartlett, BorisáC Bastian, StephenáB Baylin, Madhusmita Behera, Dmitry Belyaev, Christopher Benz, Brady Bernard, Rameen Beroukhim, Natalie Bir, AaronáD Black, Tom Bodenheimer, Lori Boice, GenevieveáM Boland, Riccardo Bono, MoizáS Bootwalla, Marcus Bosenberg, Jay Bowen, Reanne Bowlby, ChristopheráA Bristow, Laura Brockway-Lunardi, Denise Brooks, Jakub Brzezinski, Wiam Bshara, Elizabeth Buda, WilliamáR Burns, YaronáS N Butterfield, Michael Button, Tiffany Calderone, GiancarloáAntonini Cappellini, Candace Carter, ScottáL Carter, Lynn Cherney, AndrewáD Cherniack, Aaron Chevalier, Lynda Chin, Juok Cho, RaymondáJ Cho, Yoon-La Choi, Andy Chu, Sudha Chudamani, Kristian Cibulskis, Giovanni Ciriello, Amanda Clarke, Stephen Coons, Leslie Cope, Daniel Crain, Erin Curley, Ludmila Danilova, Stefania D’Atri, Tanja Davidsen, MichaeláA Davies, KeitháA Delman, JohnáA Demchok, QixiaáA Deng, YonathanáLissanu Deribe, Noreen Dhalla, Rajiv Dhir, Daniel DiCara, Michael Dinikin, Michael Dubina, J áStephen Ebrom, Sophie Egea, Greg Eley, Jay Engel, JenniferáM Eschbacher, KonstantináV Fedosenko, Ina Felau, Timothy Fennell, MartináL Ferguson, Sheila Fisher, KeitháT Flaherty, Scott Frazer, Jessica Frick, Victoria Fulidou, StaceyáB Gabriel, Jianjiong Gao, Johanna Gardner, LeviáA Garraway, JulieáM Gastier-Foster, Carmelo Gaudioso, Nils Gehlenborg, Giannicola Genovese, Mark Gerken, JeffreyáE Gershenwald, Gad Getz, Carmen Gomez-Fernandez, Thomas Gribbin, Jonna Grimsby, Benjamin Gross, Ranabir Guin, Tony Gutschner, Angela Hadjipanayis, Ruth Halaban, Benjamin Hanf, David Haussler, LaurenáE Haydu, D áNeil Hayes, NicholasáK Hayward, DavidáI Heiman, Lynn Herbert, JamesáG Herman, Peter Hersey, KatherineáA Hoadley, Eran Hodis, RobertáA Holt, DaveáSB Hoon, Susan Hoppough, AlanáP Hoyle, FranklináW Huang, Mei Huang, Sharon Huang, CarolynáM Hutter, Matthew Ibbs, Lisa Iype, Anders Jacobsen, Valerie Jakrot, Alyssa Janning, WilliamáR Jeck, StuartáR Jefferys, MarkáA Jensen, CorbináD Jones, StevenáJ M Jones, Zhenlin Ju, Hojabr Kakavand, Hyojin Kang, RichardáF Kefford, FadloáR Khuri, Jaegil Kim, JohnáM Kirkwood, Joachim Klode, Anil Korkut, Konstanty Korski, Michael Krauthammer, Raju Kucherlapati, LawrenceáN Kwong
发表日期
2015/6/18
期刊
Cell
卷号
161
期号
7
页码范围
1681-1696
出版商
Elsevier
简介
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a Tácell marker, were associated with improved patient survival. This clinicopathological and multi …
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