作者
Cancer Genome Atlas Research Network Tissue source sites: Duke University Medical School McLendon Roger 1 Friedman Allan 2 Bigner Darrell 1, Emory University Van Meir Erwin G. 3 4 5 Brat Daniel J. 5 6 M. Mastrogianakis Gena 3 Olson Jeffrey J. 3 4 5, Henry Ford Hospital Mikkelsen Tom 7 Lehman Norman 8, MD Anderson Cancer Center Aldape Ken 9 Alfred Yung WK 10 Bogler Oliver 11, University of California San Francisco VandenBerg Scott 12 Berger Mitchel 13 Prados Michael 13, Johns Hopkins/University of Southern California Laird Peter W. 31 Cope Leslie 32 Herman James G. 33 Weisenberger Daniel J. 31 Pan Fei 31 Van Den Berg David 31 Van Neste Leander 34 Mi Yi Joo 33 Schuebel Kornel E. 33 Baylin Stephen B. 33, HudsonAlpha Institute/Stanford University Absher Devin M. 35 Li Jun Z. 36 Southwick Audrey 37 Brady Shannon 37 Aggarwal Amita 37 Chung Tisha 37 Sherlock Gavin 37 Brooks James D. 38 Myers Richard M. 35, University of North Carolina, Chapel Hill Perou Charles M. 49 50 Neil Hayes D. 51 Topal Michael D. 50 52 Hoadley Katherine A. 49 Qi Yuan 51 Balu Sai 52 Shi Yan 52 Wu Junyuan 52, Biospecimen Core Resource Penny Robert 53 Bittner Michael 54 Shelton Troy 53 Lenkiewicz Elizabeth 53 Morris Scott 53 Beasley Debbie 53 Sanders Sheri 53, Data Coordinating Center Kahn Ari 55 Sfeir Robert 55 Chen Jessica 55 Nassau David 55 Feng Larry 55 Hickey Erin 55 Zhang Jinghui 56 Weinstein John N. 57, Project teams: National Cancer Institute Barker Anna 58 Gerhard Daniela S. 58 Vockley Joseph 58 Compton Carolyn 58 Vaught Jim 58 Fielding Peter 58 Ferguson Martin L. 59 Schaefer Carl 56 Madhavan Subhashree 56 Buetow Kenneth H. 56, National Human Genome Research Institute Collins Francis 60 Good Peter 60 Guyer Mark 60 Ozenberger Brad 60 Peterson Jane 60 Thomson Elizabeth 60
发表日期
2008/10/23
期刊
Nature
卷号
455
期号
7216
页码范围
1061-1068
出版商
Nature Publishing Group UK
简介
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas—the most common type of adult brain cancer—and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol-3-OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma …
引用总数
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Cancer Genome Atlas Research Network Tissue … - Nature, 2008