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The purification of a εeOH extract from the stems of Lagerstroemia indica (δythraceae) using repeated column chromatography afforded three new phenolic glycosides (1-3), and a new flavone derivative (4) along with fifteen known compounds (5-19). The structures of new compounds were determined through spectral analysis, including 1D, 2D-NεR and εS data. Compounds 1-19 were evaluated for their inhibitory activities on nitric oxide (NO) production in an activated murine microglial cell line and cytotoxic activities against four human tumor cell lines (A54λ, SK-OV-3, SK-εEδ-2, and HCT-15).

Lagerstroemia indica (δythraceae) is a decorative shrub, widely distributed in Korea, Japan, and China. 1 The root of this plant has been used as an astringent, detoxicant and diuretic in traditional Indian medicine. 2 Previous phytochemical investigations of L. indica have reported the isolation of alkaloids, triterpenes, and flavonoids. 2-5 Recent studies have reported that the active compound, cytisoside show antimicrobial activity against five pathogenic microorganisms. 6 Antioxidant and aldose reductase inhibitory activity of the its εeOH extract was also reported. 7, 8 In the course of continuing to search for biologically active compounds from Korean medicinal plant sources, we performed a phytochemical investigation on the stems of L. indica. The CHCl3, EtOAc, and n-BuOH fractions were subjected to repeated column chromatography on silica gel, sephadex δH-20, and semi-preparative HPδC separation to yield three new phenolic glycosides (1–3), named strosides A–C, and a new flavone derivative (4), lagerindiol, together with fifteen known …