作者
Myriam Chalabi, Lorenzo F Fanchi, Krijn K Dijkstra, José G Van den Berg, Arend G Aalbers, Karolina Sikorska, Marta Lopez-Yurda, Cecile Grootscholten, Geerard L Beets, Petur Snaebjornsson, Monique Maas, Marjolijn Mertz, Vivien Veninga, Gergana Bounova, Annegien Broeks, Regina G Beets-Tan, Thomas R de Wijkerslooth, Anja U van Lent, Hendrik A Marsman, Elvira Nuijten, Niels F Kok, Maria Kuiper, Wieke H Verbeek, Marleen Kok, Monique E Van Leerdam, Ton N Schumacher, Emile E Voest, John B Haanen
发表日期
2020/4
期刊
Nature medicine
卷号
26
期号
4
页码范围
566-576
出版商
Nature Publishing Group
简介
PD-1 plus CTLA-4 blockade is highly effective in advanced-stage, mismatch repair (MMR)-deficient (dMMR) colorectal cancers, yet not in MMR-proficient (pMMR) tumors. We postulated a higher efficacy of neoadjuvant immunotherapy in early-stage colon cancers. In the exploratory NICHE study (ClinicalTrials. gov: NCT03026140), patients with dMMR or pMMR tumors received a single dose of ipilimumab and two doses of nivolumab before surgery, the pMMR group with or without celecoxib. The primary objective was safety and feasibility; 40 patients with 21 dMMR and 20 pMMR tumors were treated, and 3 patients received nivolumab monotherapy in the safety run-in. Treatment was well tolerated and all patients underwent radical resections without delays, meeting the primary endpoint. Of the patients who received ipilimumab+ nivolumab (20 dMMR and 15 pMMR tumors), 35 were evaluable for efficacy and …
学术搜索中的文章
M Chalabi, LF Fanchi, KK Dijkstra, JG Van den Berg… - Nature medicine, 2020