作者
Renu R Bahadoer, Esmée A Dijkstra, Boudewijn van Etten, Corrie AM Marijnen, Hein Putter, Elma Meershoek-Klein Kranenbarg, Annet GH Roodvoets, Iris D Nagtegaal, Regina GH Beets-Tan, Lennart K Blomqvist, Tone Fokstuen, Albert J Ten Tije, Jaume Capdevila, Mathijs P Hendriks, Ibrahim Edhemovic, Andrés Cervantes, Per J Nilsson, Bengt Glimelius, Cornelis JH van de Velde, Geke AP Hospers, L Østergaard, F Svendsen Jensen, P Pfeiffer, KEJ Jensen, MP Hendriks, WH Schreurs, HP Knol, JJ van der Vliet, JB Tuynman, AME Bruynzeel, ED Kerver, S Festen, ME van Leerdam, GL Beets, LGH Dewit, CJA Punt, PJ Tanis, ED Geijsen, P Nieboer, WA Bleeker, AJ Ten Tije, RMPH Crolla, ACM van de Luijtgaarden, JWT Dekker, JM Immink, FJF Jeurissen, AWKS Marinelli, HM Ceha, TC Stam, P Quarles an Ufford, WH Steup, ALT Imholz, RJI Bosker, JHM Bekker, GJ Creemers, GAP Nieuwenhuijzen, H Van Den Berg, WM van der Deure, RF Schmitz, JM van Rooijen, AFT Olieman, ACM van den Bergh, DJA de Groot, K Havenga, JC Beukema, J De Boer, PHJM Veldman, EJM Siemerink, JWP Vanstiphout, B De Valk, QAJ Eijsbouts, MB Polée, C Hoff, A Slot, HW Kapiteijn, KCMJ Peeters, FP Peters, PA Nijenhuis, SA Radema, H De Wilt, P Braam, GJ Veldhuis, D Hess, T Rozema, O Reerink, D Ten Bokkel Huinink, A Pronk, J Vos, M Tascilar, GA Patijn, C Kersten, O Mjåland, M Grønlie Guren, AN Nesbakken, J Benedik, I Edhemovic, V Velenik, J Capdevila, E Espin, R Salazar, S Biondo, V Pachón, J Die Trill, J Aparicio, E Garcia Granero, MJ Safont, JC Bernal, A Cervantes, A Espí Macías, L Malmberg, G Svaninger, H Hörberg, G Dafnis, A Berglund, L Österlund, K Kovacs, J Hol, S Ottosson, G Carlsson, C Bratthäll, J Assarsson, BL Lödén, P Hede, I Verbiené, O Hallböök, A Johnsson, ML Lydrup, K Villmann, P Matthiessen, JH Svensson, J Haux, S Skullman, T Fokstuen, T Holm, P Flygare, M Walldén, B Lindh, O Lundberg, C Radu, L Påhlman, A Piwowar, K Smedh, U Palenius, S Jangmalm, P Parinkh, H Kim, ML Silviera
发表日期
2021/1/1
期刊
The Lancet Oncology
卷号
22
期号
1
页码范围
29-42
出版商
Elsevier
简介
Background
Systemic relapses remain a major problem in locally advanced rectal cancer. Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation (RAPIDO) trial aimed to reduce distant metastases without compromising locoregional control.
Methods
In this multicentre, open-label, randomised, controlled, phase 3 trial, participants were recruited from 54 centres in the Netherlands, Sweden, Spain, Slovenia, Denmark, Norway, and the USA. Patients were eligible if they were aged 18 years or older, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0–1, had a biopsy-proven, newly diagnosed, primary, locally advanced rectal adenocarcinoma, which was classified as high risk on pelvic MRI (with at least one of the following criteria: clinical tumour [cT] stage cT4a or cT4b, extramural …
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