作者
Ariane Gagnon, Michael Walsh, Tika Okuda, Katrina Y Choe, Cristian Zaelzer, Charles W Bourque
发表日期
2014/10/1
期刊
The Journal of Physiology
卷号
592
期号
19
页码范围
4177-4186
简介
Key points
- Magnocellular neurosecretory cells (MNCs) of the rat supraoptic nucleus adopt bursting activity patterns under conditions demanding maximum peptide release from their nerve endings in the neurohypophysis.
- Exogenous activation of NMDA receptors (NMDARs) induces spike clustering in MNCs through a mechanism that requires apamin‐sensitive small conductance calcium‐activated K+ (SK) channels).
- Here we show that NMDAR‐ and SK channel‐dependent spike clustering can be induced in MNCs by release of endogenous glutamate from afferent axon terminals.
- This form of bursting activity can be modulated by subtle changes in membrane voltage, or by partial inhibition of SK channels.
Abstract
Magnocellular neurosecretory cells (MNCs) in the rat supraoptic nucleus display clustered firing during hyperosmolality or dehydration. This response is beneficial because this type of activity …
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A Gagnon, M Walsh, T Okuda, KY Choe, C Zaelzer… - The Journal of Physiology, 2014