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Background:

A few studies have been carried on preventive drugs for apnea of preterm neonates.

Objectives:

This study aimed to assess the safety and prophylactic effects of aminophylline on the incidence of apnea in premature neonates.

Patients and Methods:

This study was a randomized clinical trial (RCT) research. The prophylactic effect of aminophylline on apnea was investigated in premature babies in our NICU (IRAN-Isfahan). In the study group (A), 5 mg/kg aminophylline was initially administered as a loading dose. Then, every 8 hours, 1.5 mg/kg was given as maintenance dose for the next 10 days. In the control group (C), no aminophylline was used during the first ten days of life.

Results:

Fifty-two neonates were randomized for the study and all of them completed it. Primary outcomes were clearly different between the two groups. Only 2 infants (7.7%) who had been placed in aminophylline group …