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Dear Editor, Since the first case of COVID-19 was reported in Wuhan, this new respiratory disease has evolved rapidly and been found in almost all the countries in the world. From our clinical experiences during managing COVID-19 patients, we observed an extremely high fatality rate in invasive ventilation (IV) patients which was astonishing and unexpected.

To validate our assumption, we collected and analyzed the data of 469 ICU COVID-19 patients who were hospitalized from February 2020 to the end of March in 13 ICUs in Wuhan. At the time of data collection, all of the patients were either discharged or deceased (Table 1). Clinical features, laboratory results on admission, and outcomes are shown in Table 2. We found that the mortality rate in the IV group was 92%, compared to the other two groups (6.4% in the NV group, 40.8% in the NIV group). Furthermore, patients in the IV group developed a higher rate …