作者
Vassilis Stratoulias, Jose Luis Venero, Marie‐Ève Tremblay, Bertrand Joseph
发表日期
2019/9/2
来源
The EMBO journal
卷号
38
期号
17
页码范围
e101997
简介
Microglia are brain‐resident macrophages forming the first active immune barrier in the central nervous system. They fulfill multiple functions across development and adulthood and under disease conditions. Current understanding revolves around microglia acquiring distinct phenotypes upon exposure to extrinsic cues in their environment. However, emerging evidence suggests that microglia display differences in their functions that are not exclusively driven by their milieu, rather by the unique properties these cells possess. This microglial intrinsic heterogeneity has been largely overlooked, favoring the prevailing view that microglia are a single‐cell type endowed with spectacular plasticity, allowing them to acquire multiple phenotypes and thereby fulfill their numerous functions in health and disease. Here, we review the evidence that microglia might form a community of cells in which each member (or “subtype …
引用总数
2019202020212022202320249681091268644
学术搜索中的文章
V Stratoulias, JL Venero, MÈ Tremblay, B Joseph - The EMBO journal, 2019