作者
Filiz Bilir, Dagıstan Tolga Arıoz, Suna Evrim Arıkan, Gulsum Seyma Yalcın, Cigdem Ozdemir, Hacer Demir, Mariam Chkhikvadze, Cem Yagmur Ozdemir, Nayif Cicekli, Nefize Vatansever, Sezgin Yılmaz
发表日期
2023/9
期刊
Archives of Gynecology and Obstetrics
卷号
308
期号
3
页码范围
941-946
出版商
Springer Berlin Heidelberg
简介
Purpose
Relationship between pathologic parameters, surgical parameters, or lymph node status with oncologic outcomes is not fully elucidated in endometrial cancer (EC). We want to investigate the molecular classification of uterine cancer in the Turkish population and its relationship between lymphadenectomy and lymph node metastasis.
Methods
In this study, 100 patients' clinical and pathologic data diagnosed with EC were analyzed. Pathologic and molecular parameters were investigated and compared them with clinical parameters.
Results
According to the molecular analysis, 16 patients (16%) had p53 mutation, 3 patients (3%) were classified as POLE mutant group, 38 (38%) patients in the MSI group, and the remaining 43 patients (43%) into the no specific mutation profile (NSMP) group. Lymph node metastasis rate was significantly higher in copy number high (CNH) group compared to the others. In the …
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F Bilir, DT Arıoz, SE Arıkan, GS Yalcın, C Ozdemir… - Archives of Gynecology and Obstetrics, 2023