作者
Tadeusz Dębniak, Tomasz Gromowski, Rodney J Scott, Jacek Gronwald, Tomasz Huzarski, Tomasz Byrski, Grzegorz Kurzawski, Dagmara Dymerska, Bohdan Górski, Katarzyna Paszkowska-Szczur, Cezary Cybulski, Pablo Serrano-Fernandez, Jan Lubiński
发表日期
2015/12
来源
Hereditary cancer in clinical practice
卷号
13
页码范围
1-9
出版商
BioMed Central
简介
Background
Over half the cancer deaths in HNPCC families are due to extra-colonic malignancies that include endometrial and ovarian cancers. The benefits of surveillance for gynecological cancers are not yet proven and there is no consensus on the optimal surveillance recommendations for women with MMR mutations.
Methods
We performed a systematic review of the literature and evaluated gynecological cancer risk in a series of 631 Polish HNPCC families classified into either Lynch Syndrome (LS, MMR mutations detected) or HNPCC (fulfillment of the Amsterdam or modified Amsterdam criteria).
Results
Published data clearly indicates no benefit for ovarian cancer screening in contrast to risk reducing surgery.
We confirmed a significantly increased risk of OC in Polish LS families (OR = 4,6, p < 0 …
学术搜索中的文章
T Dębniak, T Gromowski, RJ Scott, J Gronwald… - Hereditary cancer in clinical practice, 2015