作者
Santosh B Murthy, Ajay Gupta, Alexander E Merkler, Babak B Navi, Pitchaiah Mandava, Costantino Iadecola, Kevin N Sheth, Daniel F Hanley, Wendy C Ziai, Hooman Kamel
发表日期
2017/6
来源
Stroke
卷号
48
期号
6
页码范围
1594-1600
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
The safety and efficacy of restarting anticoagulation therapy after intracranial hemorrhage (ICH) remain unclear. We performed a systematic review and meta-analysis to summarize the associations of anticoagulation resumption with the subsequent risk of ICH recurrence and thromboembolism.
Methods
We searched published medical literature to identify cohort studies involving adults with anticoagulation-associated ICH. Our predictor variable was resumption of anticoagulation. Outcome measures were thromboembolic events (stroke and myocardial infarction) and recurrence of ICH. After assessing study heterogeneity and publication bias, we performed a meta-analysis using random-effects models to assess the strength of association between anticoagulation resumption and our outcomes.
Results
Eight studies were eligible for inclusion in the meta-analysis, with 5306 ICH patients …
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SB Murthy, A Gupta, AE Merkler, BB Navi, P Mandava… - Stroke, 2017