作者
Daniel F Hanley, Karen Lane, Nichol McBee, Wendy Ziai, Stanley Tuhrim, Kennedy R Lees, Jesse Dawson, Dheeraj Gandhi, Natalie Ullman, W Andrew Mould, Steven W Mayo, A David Mendelow, Barbara Gregson, Kenneth Butcher, Paul Vespa, David W Wright, Carlos S Kase, J Ricardo Carhuapoma, Penelope M Keyl, Marie Diener-West, John Muschelli, Joshua F Betz, Carol B Thompson, Elizabeth A Sugar, Gayane Yenokyan, Scott Janis, Sayona John, Sagi Harnof, George A Lopez, E Francois Aldrich, Mark R Harrigan, Safdar Ansari, Jack Jallo, Jean-Louis Caron, David LeDoux, Opeolu Adeoye, Mario Zuccarello, Harold P Adams, Michael Rosenblum, Richard E Thompson, Issam A Awad
发表日期
2017/2/11
期刊
The Lancet
卷号
389
期号
10069
页码范围
603-611
出版商
Elsevier
简介
Background
Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and serious disability for survivors. We aimed to test whether attempting to remove intraventricular haemorrhage with alteplase versus saline irrigation improved functional outcome.
Methods
In this randomised, double-blinded, placebo-controlled, multiregional trial (CLEAR III), participants with a routinely placed extraventricular drain, in the intensive care unit with stable, non-traumatic intracerebral haemorrhage volume less than 30 mL, intraventricular haemorrhage obstructing the 3rd or 4th ventricles, and no underlying pathology were adaptively randomly assigned (1:1), via a web-based system to receive up to 12 doses, 8 h apart of 1 mg of alteplase or 0·9% saline via the extraventricular drain. The treating physician, clinical research staff, and participants were masked to treatment assignment. CT scans were …
学术搜索中的文章
DF Hanley, K Lane, N McBee, W Ziai, S Tuhrim… - The Lancet, 2017