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Background: Nigeria has had poor COVID-19 vaccine uptake as a result of vaccine hesitancy, vaccine mistrust and government mismanagement of the initial COVID-19 outbreak management. It was therefore, important to assess the knowledge, attitudes towards, level of uptake and determinants of COVID-19 vaccine uptake among residents of New Benin Community and Ovbiogie Communities in Benin City in order to guide future vaccine campaigns.

Methods: The study was carried out among 1,310 respondents in New Benin and Ovbiogie communities in Benin City using a descriptive cross-sectional design and multi stage sampling technique. An adapted intervieweradministered questionnaire was used to for data collection. Sample size was calculated using ap of 0.79 and 0.70 and data analysis was carried out using IBM SPSS version 25.0 software and p< 0.05 was considered significant.

Results: This study revealed a high proportion of respondents 509 (77.4%) in Ovbiogie community had good knowledge of COVID-19 vaccine while majority of respondents 603 (92.5%) had good knowledge of COVID19 vaccines in New Benin community. Two-thirds of respondents 396 (66.0%) in New Benin had positive attitude towards COVID-19 vaccines while about half 333 (52.3%) had positive towards COVID-19 vaccines in Ovbiogie community. About one-fifth 123 (18.7%) of respondents in Ovbiogie community had ever taken the vaccines, while less than one tenth 48 (7.4%) had ever received the vaccines in New Benin community of which. Level of education, skill level, social class, knowledge of and attitude towards COVID-19 vaccines were …