作者
Álvaro J Cruz-Gómez, Noelia Ventura-Campos, Antonio Belenguer, Cesar Ávila, Cristina Forn
发表日期
2014/3
期刊
Multiple Sclerosis Journal
卷号
20
期号
3
页码范围
338-348
出版商
Sage Publications
简介
Objective
The objective of this paper is to explore differences in resting-state functional connectivity between cognitively impaired and preserved multiple sclerosis (MS) patients.
Methods
Sixty MS patients and 18 controls were assessed with the Brief Repeatable Battery of Neuropsychological Tests (BRB-N). A global Z score of the BRB-N was obtained and allowed us to classify MS patients as cognitively impaired and cognitively preserved (n = 30 per group). Functional connectivity was assessed by independent component analysis of resting-state networks (RSNs) related to cognition: the default mode network, left and right frontoparietal and salience network. Between-group differences were evaluated and a regression analysis was performed to describe relationships among cognitive status, functional connectivity and radiological variables.
Results
Compared to cognitively preserved patients and healthy controls …
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ÁJ Cruz-Gómez, N Ventura-Campos, A Belenguer… - Multiple Sclerosis Journal, 2014