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Extensive use of antibiotics for urinary tract infections has led to the emergence of drug-resistant microorganisms and one solution to this problem is to search for non-antibiotic compounds that exert anti-bacterial activity through different mechanisms such as non-steroidal anti-inflammatory drugs (NSAIDs). In this study, out of 100 urine samples; 48 Escherichia coli strains were detected, 47.9% were multi-drug resistant. The antibiogram resistance pattern of the strains was carried out by agar dilution method. Diclofenac sodium, indomethacin, aspirin and ibuprofen were tested against the E. coli isolates. Diclofenac sodium showed the lowest MIC 50 and MIC 90; 8 and 256 mg/ml, respectively. Aspirin showed MIC 50 of 64 mg/ml, while both indomethacin and ibuprofen showed MIC 50 of 256 mg/ml. Indomethacin, aspirin and ibuprofen showed the same MIC 90 of 1024 mg/ml. The combined effects of the four NSAIDs …