查看文章

The functional outcome of patients with intracranial hemorrhage strongly relates to the degree of secondary brain injury (SBI) evolving within days after the initial bleeding. The spatiotemporal interplay of specific inflammatory processes within different brain compartments has not been sufficiently characterized, limiting potential therapeutic interventions to prevent and treat SBI.

We used a whole-blood injection mouse model to systematically characterize the spatial and temporal dynamics of inflammatory processes after intracranial hemorrhage using 7-Tesla magnetic resonance imaging (MRI), spatial RNA sequencing, functional BBB assessment, and immunofluorescence-average-intensity-mapping.