作者
Antonino Naro, Antonino Leo, Antonino Cannavò, Antonio Buda, Rocco Bruno, Carlo Salviera, Placido Bramanti, Rocco Salvatore Calabrò
发表日期
2015
期刊
Neural Plasticity
卷号
2015
期号
1
页码范围
391349
出版商
Hindawi Publishing Corporation
简介
Patients suffering from chronic disorders of consciousness (DOC) are characterized by profound unawareness and an impairment of large‐scale cortical and subcortical connectivity. In this study, we applied an electrophysiological approach aimed at identifying the residual audiomotor connectivity patterns that are thought to be linked to awareness. We measured some markers of audiomotor integration (AMI) in 20 patients affected by DOC, before and after the application of a repetitive transcranial magnetic stimulation protocol (rTMS) delivered over the left primary motor area (M1), paired to a transauricular alternating current stimulation. Our protocol induced potentiating of the electrophysiological markers of AMI and M1 excitability, paired to a clinical improvement, in all of the patients with minimally conscious state (MCS) but in none of those suffering from unresponsive wakefulness syndrome (UWS). Our protocol …
引用总数
2015201620172018201920202021202220232024124132311
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