作者
Hyung-cheol Kim, Ji-Young Lee, Hyuna Sung, Ji-Yeob Choi, Sue K Park, Kyoung-Mu Lee, Young Jin Kim, Min Jin Go, Lian Li, Yoon Shin Cho, Miey Park, Dong-Joon Kim, Ji Hee Oh, Jun-Woo Kim, Jae-Pil Jeon, Soon-Young Jeon, Haesook Min, Hyo Mi Kim, Jaekyung Park, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Min Hyuk Lee, Sung-Won Kim, Jong Won Lee, Byeong-Woo Park, Woong-Yang Park, Eun-Hye Kim, Mi Kyung Kim, Wonshik Han, Sang-Ah Lee, Keitaro Matsuo, Chen-Yang Shen, Pei-Ei Wu, Chia-Ni Hsiung, Jong-Young Lee, Hyung-Lae Kim, Bok-Ghee Han, Daehee Kang
发表日期
2012/4
期刊
Breast Cancer Research
卷号
14
页码范围
1-12
出版商
BioMed Central
简介
Introduction
Although approximately 25 common genetic susceptibility loci have been identified to be independently associated with breast cancer risk through genome-wide association studies (GWAS), the genetic risk variants reported to date only explain a small fraction of the heritability of breast cancer. Furthermore, GWAS-identified loci were primarily identified in women of European descent.
Methods
To evaluate previously identified loci in Korean women and to identify additional novel breast cancer susceptibility variants, we conducted a three-stage GWAS that included 6,322 cases and 5,897 controls.
Results
In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 …
学术搜索中的文章
H Kim, JY Lee, H Sung, JY Choi, SK Park, KM Lee… - Breast Cancer Research, 2012