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This is a first case ever reported on the fullerene-based low toxic nanocationite particles (porphyrin adducts of cyclohexyl fullerene-C₆₀) designed for targeted delivery of the paramagnetic magnesium stable isotope to the heart muscle providing a sharp clinical effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24h after a single injection (0.03–0.1 LD₅₀). A whole principle of this therapy is novel: ²⁵Mg²⁺-magnetic isotope effect selectively stimulates the ATP overproduction in the oxygen-depleted cells due to ²⁵Mg²⁺ released by the nanoparticles. Being membranotropic cationites, these “smart nanoparticles” release the overactivating paramagnetic cations only in response to the metabolic acidic shift. The resulting positive changes in the heart cell energy metabolism may help to prevent and/or treat the local myocardial hypoxic disorders and, hence, protect the heart muscle from a …