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Evidence supporting the effectiveness of pancreatic cancer (PC) screening is scant. Most clinical studies concern small populations with short follow‐up durations. Mathematical models are useful to estimate long‐term effects of PC screening using short‐term indicators. This systematic review aims to evaluate the impact of PC screening on life expectancy (LE) in model‐based studies. Therefore, we searched four databases (Embase, Medline, Web‐of‐science, Cochrane) until 30 May 2022 to identify model‐based studies evaluating the impact of PC screening on LE in different risk populations. Two authors independently screened identified papers, extracted data and assessed the methodological quality of studies. A descriptive analysis was performed and the impact of screening strategies on LE of different risk groups was reported. Our search resulted in 419 studies, of which eight met the eligibility criteria …