作者
Niels Halama, Monika Braun, Christoph Kahlert, Anna Spille, Christian Quack, Nuh Rahbari, Moritz Koch, Jürgen Weitz, Matthias Kloor, Inka Zoernig, Peter Schirmacher, Karsten Brand, Niels Grabe, Christine S Falk
发表日期
2011/2/15
期刊
Clinical cancer research
卷号
17
期号
4
页码范围
678-689
出版商
American Association for Cancer Research
简介
Purpose: Tumor infiltrating T lymphocytes in colorectal cancer (CRC) have prognostic impact, but the role of natural killer (NK) cells in CRC tissue is unclear. The contribution of intratumoral cytokines and chemokines in shaping the composition of the inflammatory lymphocytic infiltrate is also unclear.
Experimental Design: In this study, localization and densities of NK and T cells within primary CRC, CRC liver metastases, adenomas, and normal tissues were analyzed on whole tissue sections from 112 patients. In a subset of these patients, the most important 50 cytokines and chemokines were quantified in paired serum, primary CRC and adjacent mucosa samples and in CRC liver metastases and correlated with NK and T-cell infiltration, respectively.
Results: The various compartments displayed characteristic differences like significantly higher chemokine concentrations in CRC …
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N Halama, M Braun, C Kahlert, A Spille, C Quack… - Clinical cancer research, 2011