作者
Jeffrey S Berger, Dennis Kunichoff, Samrachana Adhikari, Tania Ahuja, Nancy Amoroso, Yindalon Aphinyanaphongs, Meng Cao, Ronald Goldenberg, Alexander Hindenburg, James Horowitz, Sam Parnia, Christopher Petrilli, Harmony Reynolds, Emma Simon, James Slater, Shadi Yaghi, Eugene Yuriditsky, Judith Hochman, Leora I Horwitz
发表日期
2020/10
期刊
Arteriosclerosis, thrombosis, and vascular biology
卷号
40
期号
10
页码范围
2539-2547
出版商
Lippincott Williams & Wilkins
简介
Objective
To determine the prevalence of D-dimer elevation in coronavirus disease 2019 (COVID-19) hospitalization, trajectory of D-dimer levels during hospitalization, and its association with clinical outcomes.
Approach and Results
Consecutive adults admitted to a large New York City hospital system with a positive polymerase chain reaction test for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) between March 1, 2020 and April 8, 2020 were identified. Elevated D-dimer was defined by the laboratory-specific upper limit of normal (>230 ng/mL). Outcomes included critical illness (intensive care, mechanical ventilation, discharge to hospice, or death), thrombotic events, acute kidney injury, and death during admission. Among 2377 adults hospitalized with COVID-19 and ≥1 D-dimer measurement, 1823 (76%) had elevated D-dimer at presentation. Patients with elevated presenting baseline D …
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JS Berger, D Kunichoff, S Adhikari, T Ahuja, N Amoroso… - Arteriosclerosis, thrombosis, and vascular biology, 2020