作者
Jane A O’Halloran, Emily R Ko, Kevin J Anstrom, Eyal Kedar, Matthew W McCarthy, Reynold A Panettieri, Martin Maillo, Patricia Segura Nunez, Anne M Lachiewicz, Cynthia Gonzalez, P Brian Smith, Sabina Mendivil-Tuchia de Tai, Akram Khan, Alfredo J Mena Lora, Matthias Salathe, Gerardo Capo, Daniel Rodríguez Gonzalez, Thomas F Patterson, Christopher Palma, Horacio Ariza, Maria Patelli Lima, John Blamoun, Esteban C Nannini, Eduardo Sprinz, Analia Mykietiuk, Radica Alicic, Adriana M Rauseo, Cameron R Wolfe, Britta Witting, Jennifer P Wang, Luis Parra-Rodriguez, Tatyana Der, Kate Willsey, Jun Wen, Adam Silverstein, Sean M O’Brien, Hussein R Al-Khalidi, Michael A Maldonado, Richard Melsheimer, William G Ferguson, Steven E McNulty, Pearl Zakroysky, Susan Halabi, Daniel K Benjamin, Sandra Butler, Jane C Atkinson, Stacey J Adam, Soju Chang, Lisa LaVange, Michael Proschan, Samuel A Bozzette, William G Powderly, Mahendra Patel, Arun Sanyal, Jason Green, Huimin Wu, Benjamin Linas, Philip Grant, Vivek Iyer, Otto Yang, Bindu Balani, Sam Parnia, Ryan Dare, Caryn G Morse, Estelle S Harris, Glenn Wortmann, Nicholas Hill, Shama Patel, Julia Garcia-Diaz, Suman Thapamager, Megan Devine, Christine M Bojanowski, Barry Meisenberg, Gailen Marshall, Dima Dandachi, Arick Sabin, Anthony Breemo, Suman Sinha, Christopher Goss, Rebecca Reece, Arlette Aouad, Seth Glassman, Peter Morris, Bela Patel, Fatimah Bello, Juliana Cardozo Fernandes, Oscar Carbajal, Lorena Ravera, Mozar Castro, Miguel Villegas-Chiroque, Fernando Oscar Riera, Adrian Camacho, Claudio Stadnik, Jorge Gave, Rodrigo Biondi, Ronal Gamarra Velarde, Jose Cerbino Neto, Juan Ditondo, Marcelo H Losso, Mariano Dolz, Alexandra O’Sullivan, Brian Gavin, Maria Beumont-Mauviel, Huyen Ca, Rose Beci, Daniel Molina, Sandhya Rao, Thomas Stock, William Erhardt, Sarah Read, Jessica Springer, Rachel Presti, Ryley Thompson, Kimberly Gray, Cathy Henry, Alem Haile, Michael Klebert, Lisa Kessels, Kathryn Vehe, Kristopher Bakos, Teresa Spitz, Sara Hubert, Raghd Alyatim, Brittany Schneider, Chapelle Ayres, Andrej Spec, Laura Blair, Anita Afghanzada, Natalie Schodl, Lana Wahid, John J Engemann, Gloria Pinero, Beth McLendon-Arvik, Lynn Whitt, Jenny Shroba, Elizabeth Salsgiver, Candace Alleyne, Anna Gwak, Nicholas Pickell, Jack Spagnoletti, Samson Goh, Katharine Robb, Michael Cenname, Catherine Small, Markus Plate, Rodrigo Burgos, Brenna Lindsey, Fischer Herald, Stephanie Echeverria, Dorendra Lewis
发表日期
2023/7/25
期刊
Jama
卷号
330
期号
4
页码范围
328-339
出版商
American Medical Association
简介
Importance
Immune dysregulation contributes to poorer outcomes in COVID-19.
Objective
To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia.
Design, Setting, and Participants
Randomized, double-masked, placebo-controlled clinical trial using a master protocol to investigate immunomodulators added to standard care for treatment of participants hospitalized with COVID-19 pneumonia. The results of 3 substudies are reported from 95 hospitals at 85 clinical research sites in the US and Latin America. Hospitalized patients 18 years or older with confirmed SARS-CoV-2 infection within 14 days and evidence of pulmonary involvement underwent randomization between October 2020 and December 2021.
Interventions
Single infusion of abatacept (10 mg/kg; maximum dose, 1000 mg) or infliximab (5 mg/kg) or a 28-day oral course of …
学术搜索中的文章
JA O'Halloran, ER Ko, KJ Anstrom, E Kedar… - Jama, 2023
TG Stewart, PA Rebolledo, A Mourad, CJ Lindsell… - JAMA, 2023