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Anastomotic complications after low anterior resection are associated with perianastomotic ischemia. Smoking is one of the main causes of microvascular disease that is correlated with tissue ischemia. The purpose of the present study was to assess the impact of smoking on anastomotic complications after low anterior resection in rectal cancer patients.

Between January 2005 and December 2008, 412 patients underwent low anterior resection for rectal cancers by a single surgeon at Seoul National University Hospital. Excluded from this series were 197 patients with postoperative radiation therapy, cancers that were located above 10 cm from the anal verge, or lack of medical records, and the remaining 215 patients were included for analysis. Significant variables in the univariate analysis were subsequently subject to multivariate …