作者
Gábor Speer, Bertalan Cs Fekete, Taha El Hadj Othmane, Tamás Szabó, József Egresits, Erzsébet Fodor, István Kiss, Alexander G Logan, János Nemcsik, András Szabó, Zsófia K Németh, Miklós Szathmári, András Tislér
发表日期
2008/10/1
期刊
Nephrology Dialysis Transplantation
卷号
23
期号
10
页码范围
3256-3262
出版商
Oxford University Press
简介
Background. Osteoprotegerin (OPG) is a marker and regulator of arterial calcification, and it is related to cardiovascular survival in haemodialysis patients. The link between OPG and aortic stiffening—a consequence of arterial calcification—has not been previously evaluated in this population, and it is not known whether OPG-related mortality risk is mediated by arterial stiffening.
Methods. At baseline, OPG and aortic pulse wave velocity (PWV) were measured in 98 chronic haemodialysis patients who were followed for a median of 24 months. The relationship between OPG and PWV was assessed by multivariate linear regression. The role of PWV in mediating OPG related cardiovascular mortality was evaluated by including both OPG and PWV in the same survival model.
Results. At baseline mean (standard deviation) PWV was 11.2 (3.3) m/s and median OPG (interquartile range …
学术搜索中的文章
G Speer, BC Fekete, T El Hadj Othmane, T Szabó… - Nephrology Dialysis Transplantation, 2008