作者
Noriko Yuyama, Donna E Davies, Mina Akaiwa, Keiko Matsui, Yuhei Hamasaki, Yoshinori Suminami, Ning Lu Yoshida, Miyako Maeda, Anita Pandit, James L Lordan, Yumiko Kamogawa, Kazuhiko Arima, Fumio Nagumo, Mitsuhiko Sugimachi, Ann Berger, Ivan Richards, Steven L Roberds, Tetsuji Yamashita, Fumio Kishi, Hiroshi Kato, Ken-Ichi Arai, Koichi Ohshima, Jutaro Tadano, Naotaka Hamasaki, Shoichiro Miyatake, Yuji Sugita, Stephen T Holgate, Kenji Izuhara
发表日期
2002/9/1
期刊
Cytokine
卷号
19
期号
6
页码范围
287-296
出版商
Academic Press
简介
Bronchial asthma is a complex disease characterized by airway inflammation involving interleukin (IL)-4 and IL-13. We have applied microarray analyses to human bronchial epithelial cultures to probe for genes regulated by these cytokines and have identified a subset of disease-relevant genes by comparison with cDNA libraries derived from normal and asthmatic bronchial biopsies. Squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, showed the highest expression by IL-4 and IL-13, and particularly, SCCA1 was significantly increased in the asthmatic cDNA library. STAT6 was shown to be involved in expression of SCCA1 and SCCA2 in vitro. Furthermore, serum levels of SCCA were also elevated in asthmatic patients. Taken together, it was supposed that SCCA may play some role in the pathogenesis of bronchia asthma, and measuring its serum …
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N Yuyama, DE Davies, M Akaiwa, K Matsui… - Cytokine, 2002