作者
Jaewon Yang, Won-Myong Bahk, Hyun-Sang Cho, Yang-Whan Jeon, Duk-In Jon, Hee-Yeon Jung, Chan-Hyung Kim, Hee-Cheol Kim, Yong-Ku Kim, Young-Hoon Kim, Jun-Soo Kwon, Sang-Yeol Lee, Seung-Hwan Lee, Jung-Seo Yi, Bo-Hyun Yoon, Seung-Hyun Kim
发表日期
2010/7/1
期刊
Clinical neuropharmacology
卷号
33
期号
4
页码范围
169-175
出版商
LWW
简介
Objectives:
The objective of this study was to evaluate the efficacy and tolerability of blonanserin for the treatment of Korean patients with schizophrenia using a double-blind risperidone-compared design.
Methods:
Patients aged 18 to 65 years with schizophrenia were randomly assigned to blonanserin or risperidone treatment for 8 weeks. The efficacy was assessed using the mean change in Positive and Negative Syndrome Scale score total scores from baseline to week 8. Safety assessments included monitoring of vital signs, a physical examination, laboratory tests, and adverse events.
Results:
Of 206 randomly enrolled patients, 103 receiving blonanserin and 103 receiving risperidone were included in the analysis. In this study, noninferiority between blonanserin and risperidone was demonstrated. The mean change in the Positive and Negative Syndrome Scale total score at the final evaluation time point was …
学术搜索中的文章
J Yang, WM Bahk, HS Cho, YW Jeon, DI Jon, HY Jung… - Clinical neuropharmacology, 2010