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Anti-Müllerian hormone (AMH) is produced by granulosa cells during follicular development where it inhibits the transition from primordial to primary follicles. It also regulates the FSH sensitivity of early antral stages during dominant follicle selection (Broer et al., 2014). The inhibitory effect of AMH on primordial follicle activation has been described in several mammals (Durlinger et al., 2002; Nilsson et al., 2007; Yang et al., 2017) and has been considered the main mechanism maintaining the pool of primordial follicles from early exhaustion (Moolhuijsen and Visser, 2020). Other than the established role of AMH as an inhibitory molecule on follicle activation and the regulation of FSH sensitivity, it is important to decipher if AMH has any other functions. The December edition of the ESHRE Journal Club discussed a basic science research paper by Zhou et al.(2022), in which an additional role of AMH was suggested …