发明者
Luz Amalia Rios Vasquez, Rogelio Ocampo Cardona, Sandra Milena Duque, Sara Maria Robledo Restrepo, Ivan Dario Velez Bernal, David Leonardo Cedeño Medina, Marjorie Ann Jones
发表日期
2015/9/29
专利局
US
专利号
9145352
专利申请号
13484233
简介
The use of quaternary halogenated ammonium salts for treating leishmaniasis infections and other parasitic diseases is described. Although there have been previous reports in which quaternary ammonium salts are used as antimalarial, antifungal, and antileishmanial compounds, the use of such salts containing a halogenated N-methyl substituent as a therapeutic agent against leishmaniasis had not been reported. The compounds described here, in specific those with a terminal arylalkenyl or diarylalkenyl moiety, are shown to inhibit the growth of Leishmania panamensis parasites, a known causative agent of leishmaniasis disease. In addition, the series of compounds are also extensive against malaria, Chagas disease, toxoplasmosis, and other parasitic diseases.
学术搜索中的文章
LAR Vasquez, RO Cardona, SM Duque, SMR Restrepo… - US Patent 9,145,352, 2015