查看文章

With an aging US population, the occurrence of injuries and degenerative conditions are subsequently on the rise. As a direct result, there is an increase in demand for therapies that are able to repair damaged tissues and produce replacement organs.[1] In particular, there is a great need for new bioactive materials that can direct stem cell differentiation and facilitate the formation of functional tissues.[2] Several types of bioactive material that have clinical relevance have been reported for musculoskeletal tissue engineering in the last few years, including bioactive glasses (Na 2O–CaO–SiO 2–P2o 5), hydroxyapatite (HA)(Ca 10 (PO 4) 6 (OH) 2), β-tricalcium phosphate (TCP)(Ca 3 (PO 4) 2), β-wollastonite (CaO-SiO 2), and AW (Apatite-Wollastonite) glass ceramic.[3] Difficulties persisting with many of these known materials include lack of osteoinductive properties, poor processing abilities, and insufficient degradation.