作者
Asadollah Mohammadi, Hashem Khanbabaei, Rasoul Nasiri-Kalmarzi, Farzad Khademi, Mohammad Jafari, Nader Tajik
发表日期
2020/12/1
来源
Journal of Microbiology, Immunology and Infection
卷号
53
期号
6
页码范围
827-835
出版商
Elsevier
简介
Polymorphisms of vitamin D receptors (VDRs), ApaI, BsmI, FokI, and TaqI might affect susceptibility to tuberculosis (TB). In this systematic review and meta-analysis, all published articles which investigated the effects of these polymorphisms on the risk of TB in the Iranian population were retrieved.
PubMed and Scopus were searched with no date or language restrictions. In this meta-analysis, the Comprehensive Meta-Analysis (CMA) version 2.0 and random effects model were applied. The association of polymorphisms with TB risk was assessed by measuring the odds ratio (ORs) at 95% CI. Heterogeneity was investigated based on Cochran Q-test and I2-index statistics. The significance level was set at 0.05. Also, Egger's regression intercept was determined to measure publication bias.
A total of six articles on Iranian populations were included. TaqI (5/6 included studies) showed a significant association with the …
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