作者
PCRT Sohoni, CR Tyler, K Hurd, J Caunter, M Hetheridge, T Williams, C Woods, M Evans, R Toy, M Gargas, JP Sumpter
发表日期
2001/7/15
期刊
Environmental science & technology
卷号
35
期号
14
页码范围
2917-2925
出版商
American Chemical Society
简介
Bisphenol A (BPA), a high-volume chemical used to make polycarbonate plastic, epoxy resins, and other chemicals has been reported to be weakly estrogenic. To investigate the effects of long-term exposure to Bisphenol A, a multi-generation study was conducted in which fathead minnows (Pimephales promelas) were exposed to water concentrations of BPA in the range from 1 to 1280 μg/L. In this paper, we report the growth and reproductive effects of BPA on sexually mature adults in the F0 generation (after 43, 71, and 164 d of exposure) and the effects on hatchability in the F1 generation. Mean measured concentrations of BPA in the water for all doses, over a 164-d exposure period, were between 70% and 96% of nominal. An inhibitory effect of BPA on somatic growth (length and weight) occurred in adult male fish exposed to 640 and 1280 μg/L (after 71 and 164 d). BPA induced vitellogenin synthesis (VTG; a …
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