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  Cell therapy
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  The paracrine hypothesis
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  Exosomes
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  Collection CMPC secreted exosomes
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  Conditioned medium and exosomes in in vitro scratch wound assay
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  Exosomal signalling via MMP and EMMPRIN
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  Discussion

Patients suffering from heart failure as a result of myocardial infarction are in need of heart transplantation. Unfortunately the number of donor hearts is very low and therefore new therapies are subject of investigation. Cell transplantation therapy upon myocardial infarction is a very promising strategy to replace the dead myocardium with viable cardiomyocytes, smooth muscle cells and endothelial cells, thereby reducing scarring and improving cardiac performance. Despite promising results, resulting in reduced infarct size and improved cardiac function on short term, only a few cells survive the ischemic milieu and are retained in the heart, thereby minimizing long‐term effects …