作者
Joost PG Sluijter, Wilco PC Pulskens, Arjan H Schoneveld, Evelyn Velema, Chaylendra F Strijder, Frans Moll, Jean-Paul de Vries, Jan Verheijen, Roeland Hanemaaijer, Dominique PV de Kleijn, Gerard Pasterkamp
发表日期
2006/1/1
期刊
Stroke
卷号
37
期号
1
页码范围
235-239
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose— We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics.
Methods— Carotid atherosclerotic plaques (n=150) were stained and analyzed for the presence of collagen, smooth muscle cell (SMC), and macrophages. Adjacent segments were used to isolate total protein to assess MMP-2 and MMP-9 activities and gelatin breakdown, MMP-8 activity, and EMMPRIN levels.
Results— Macrophage-rich lesions revealed higher MMP-8 and MMP-9 activities, whereas SMC-rich lesions showed higher MMP-2 activity. The levels of less glycosylated EMMPRIN-45kD were higher in SMC-rich lesions and lower in macrophage-rich plaques. EMMPRIN-45kD was associated with MMP-2 levels, whereas EMMPRIN-58kD was related to MMP-9 levels.
Conclusions …
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