作者
Brian Nils Lundstrom, Michael Famulare, Larry B Sorensen, William J Spain, Adrienne L Fairhall
发表日期
2009/10
期刊
Journal of computational neuroscience
卷号
27
页码范围
277-290
出版商
Springer US
简介
Neuronal responses are often characterized by the firing rate as a function of the stimulus mean, or the f–I curve. We introduce a novel classification of neurons into Types A, B−, and B+ according to how f–I curves are modulated by input fluctuations. In Type A neurons, the f–I curves display little sensitivity to input fluctuations when the mean current is large. In contrast, Type B neurons display sensitivity to fluctuations throughout the entire range of input means. Type B− neurons do not fire repetitively for any constant input, whereas Type B+ neurons do. We show that Type B+ behavior results from a separation of time scales between a slow and fast variable. A voltage-dependent time constant for the recovery variable can facilitate sensitivity to input fluctuations. Type B+ firing rates can be approximated using a simple “energy barrier” model.
学术搜索中的文章
BN Lundstrom, M Famulare, LB Sorensen, WJ Spain… - Journal of computational neuroscience, 2009