作者
Fernando G Zampieri, Flávia R Machado, Rodrigo S Biondi, Flávio GR Freitas, Viviane C Veiga, Rodrigo C Figueiredo, Wilson J Lovato, Cristina P Amêndola, Ary Serpa-Neto, Jorge LR Paranhos, Marco AV Guedes, Eraldo A Lúcio, Lúcio C Oliveira-Júnior, Thiago C Lisboa, Fábio H Lacerda, Israel S Maia, Cintia MC Grion, Murillo SC Assunção, Airton LO Manoel, João M Silva-Junior, Péricles Duarte, Rafael M Soares, Tamiris A Miranda, Lucas M De Lima, Rodrigo M Gurgel, Denise M Paisani, Thiago D Corrêa, Luciano CP Azevedo, John A Kellum, Lucas P Damiani, Nilton Brandão Da Silva, Alexandre B Cavalcanti, Rodrigo Biondi, Renato B Chaves, Amanda R Santos, Vitor S Barzilai, Flávio GR de Freitas, Nathaly F Nunes, Rodrigo C da Cunha, Elijane F Alves, Rodrigo B Bortolini, Cintia L Sartori, Eduardo S Marques, Maria A de Sousa, Danieri YV Tomotani, Bruno G Dantas, Leonardo C Palma, Fábio L da Silva, Cristina P Amendola, Luciana C Sanches, Fernanda AM Scuoteguazza, Ligia Z de Britto, Ary Serpa, Niklas S Campos, Fabio B Hohmann, Guilherme B Olivato, Iany G da Silva, Adilson de C Meireles, Juliana C Coelho, Maiko M Silveira, Agnes C Lisboa, Luiz CS Passos, Daniela C Dorta, Ramana A Rangel, Eraldo de A Lúcio, Eduardo B Tondo, Pablo AA Vaz, Paula K de Oliveira, Lúcio C de Oliveira, Paulo HP Ferreira, Patrick HS Sampaio, Maurício GS Serra, Caroline Fachini, André P Torelly, Alldren Souza, Eliana VN Martins, Bruno AMP Besen, Carlos E Brandão, João M Silva, Flávio WF Melo, Flávio A dos Santos, Cássio L Zandonai, Eduardo Berbigier, Cíntia MC Grion, Josiane Festti, Ana Luiza Mezzaroba, José Andrade, Marianne S Camargo, Adriano F Teixeira, José de S Andrade, Michele MG de Godoy, Andréia de FT de Mendonça, Mara LFS Mendes, Renata CIC Beltrão, Edson Romano, Marcelo LP Romano, Andre F Costa, Jorge Farran, Felipe Dal-Pizzol, Danusa Damásio, Renata Gonçalves, Émerson B da Silva, Luiz de F Ferreira, Rafael L da Costa, Kellen Lopes, Miquéias ML Silva, Renata de A Marques, Glauco A Westphal, Miriam C Machado, Juliano Ramos, Luiz MS Malbouisson, Bruno N Lucena, Marlus M Thompson, Lanese M Figueiredo, Luana F Mourão, Thiago S Garces, Israel da S Maia, Jaqueline F Rohr, Fernanda Fontanela, Cassia PB Martins, Álvaro Rea, Fernanda Reese, Mirella Oliveira, André LN Gobatto, Luciana S de Mattos, Carolaine B de Oliveira, Meton S de Alencar, Jussara A Arraes, João GT Alves, Thiago C De Morais, Antônio AP Fagundes, Roberta T Tallarico, Thais Coutinho, Ronald Torres, Fernando JS Ramos, Fernanda C Athalla, Mauricio HC dos Santos, Paulo MG Nose, Cássia R Shinotsuka, Pedro Kurtz, Bruno Guimarães, Luciana G Pereira, Raquel B Jupato, Bruno de A Bravim, Marcos F Knibel, Allan S da Silva, Vinícius G de Luca, Niklas Soderberg, Roseny dos R Rodrigues, Luis EP Pfingsten
发表日期
2021/9/7
期刊
Jama
卷号
326
期号
9
页码范围
818-829
出版商
American Medical Association
简介
Importance
Intravenous fluids are used for almost all intensive care unit (ICU) patients. Clinical and laboratory studies have questioned whether specific fluid types result in improved outcomes, including mortality and acute kidney injury.
Objective
To determine the effect of a balanced solution vs saline solution (0.9% sodium chloride) on 90-day survival in critically ill patients.
Design, Setting, and Participants
Double-blind, factorial, randomized clinical trial conducted at 75 ICUs in Brazil. Patients who were admitted to the ICU with at least 1 risk factor for worse outcomes, who required at least 1 fluid expansion, and who were expected to remain in the ICU for more than 24 hours were randomized between May 29, 2017, and March 2, 2020; follow-up concluded on October 29, 2020. Patients were randomized to 2 different fluid types (a balanced solution vs saline solution reported in this article) and 2 different infusion …
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FG Zampieri, FR Machado, RS Biondi, FGR Freitas… - Jama, 2021