作者
Jun-Bean Park, Gilwoo Choi, Eun Ju Chun, Hyun Jin Kim, Jonghanne Park, Ji-Hyun Jung, Min-Ho Lee, Hiromasa Otake, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Bernard De Bruyne, Charles A Taylor, Bon-Kwon Koo
发表日期
2016/10/15
期刊
Heart
卷号
102
期号
20
页码范围
1655-1661
出版商
BMJ Publishing Group Ltd and British Cardiovascular Society
简介
Objective
To assess the distribution of pressure and shear-related forces acting on atherosclerotic plaques and their association with lesion characteristics using coronary CT angiography (cCTA)-based computational fluid dynamics (CFD) model of epicardial coronary arteries.
Methods
Patient-specific models of epicardial coronary arteries were reconstructed from cCTA in 80 patients (12 women, 63.8±9.0 years). The pressure and wall shear stress (WSS) in left anterior descending coronary arteries were assessed using CFD. High-risk plaques were defined as the presence of at least one of the following adverse plaque characteristics: low-density plaque, positive remodelling, napkin-ring sign and spotty calcification.
Results
At resting condition, 39.5% of stenotic segments (% diameter stenosis 52.3±14.4%) were exposed to high WSS (>40 dyne/cm2). When the stenotic lesion was subdivided into three segments …
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JB Park, G Choi, EJ Chun, HJ Kim, J Park, JH Jung… - Heart, 2016