作者
Gilwoo Choi, Joo Myung Lee, Hyun-Jin Kim, Jun-Bean Park, Sethuraman Sankaran, Hiromasa Otake, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Charles A Taylor, Bon-Kwon Koo
发表日期
2015/10/1
期刊
Cardiovascular Imaging
卷号
8
期号
10
页码范围
1156-1166
出版商
American College of Cardiology Foundation
简介
Objectives
The purpose of this study was to characterize the hemodynamic force acting on plaque and to investigate its relationship with lesion geometry.
Background
Coronary plaque rupture occurs when plaque stress exceeds plaque strength.
Methods
Computational fluid dynamics was applied to 114 lesions (81 patients) from coronary computed tomography angiography. The axial plaque stress (APS) was computed by extracting the axial component of hemodynamic stress acting on stenotic lesions, and the axial lesion asymmetry was assessed by the luminal radius change over length (radius gradient [RG]). Lesions were divided into upstream-dominant (upstream RG > downstream RG) and downstream-dominant lesions (upstream RG < downstream RG) according to the RG.
Results
Thirty-three lesions (28.9%) showed net retrograde axial plaque force. Upstream APS linearly increased as lesion …
学术搜索中的文章
G Choi, JM Lee, HJ Kim, JB Park, S Sankaran, H Otake… - Cardiovascular Imaging, 2015