作者
Diego Centonze, Roberto Floris, Matteo Stefanini, Silvia Rossi, Sebastiano Fabiano, Maura Castelli, Simone Marziali, Alessio Spinelli, Caterina Motta, Francesco G Garaci, Giorgio Bernardi, Giovanni Simonetti
发表日期
2011/7
期刊
Annals of neurology
卷号
70
期号
1
页码范围
52-59
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
It is still unclear whether chronic cerebrospinal venous insufficiency (CCSVI) is associated with multiple sclerosis (MS), because substantial methodological differences have been claimed by Zamboni to account for the lack of results of other groups. Furthermore, the potential role of venous malformations in influencing MS severity has not been fully explored. This information is particularly relevant, because uncontrolled surgical procedures are increasingly offered to MS patients to treat their venous stenoses.
Methods
In the present study, CCSVI was studied in 84 MS patients and in 56 healthy subjects by applying the Zamboni method for CCSVI identification.
Results
We found no significant differences (p = 0.12) in CCSVI frequency between MS and control subjects. Furthermore, no differences were found between CCSVI‐positive and CCSVI‐negative patients in terms of relevant clinical variables …
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D Centonze, R Floris, M Stefanini, S Rossi, S Fabiano… - Annals of neurology, 2011