作者
Zixuan Lin, Chantelle Lim, Dengrong Jiang, Anja Soldan, Corinne Pettigrew, Kumiko Oishi, Yuxin Zhu, Abhay Moghekar, Peiying Liu, Marilyn Albert, Hanzhang Lu
发表日期
2023/2
期刊
Alzheimer's & Dementia
卷号
19
期号
2
页码范围
569-577
简介
Introduction
Oxygen extraction fraction (OEF) reflects the balance between oxygen delivery and consumption. We longitudinally measured OEF in older adults to examine the relationship with markers of Alzheimer's disease (AD) and vascular pathology.
Methods
One hundred thirty‐seven participants were studied at two time‐points at an interval of 2.16 years. OEF was measured using T2‐relaxation‐under‐spin‐tagging (TRUST) magnetic resonance imaging (MRI). The association between OEF and vascular risks, white matter hyperintensities (WMH), cerebrospinal fluid (CSF) measures of amyloid beta (Aβ), total tau (t‐tau), and phosphorylated tau 181 (p‐tau181) was examined.
Results
OEF increased from baseline to follow‐up. The increase in OEF was more prominent in individuals with high vascular risks compared to those with low vascular risks, and was associated with progression of vascular risks and …
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Z Lin, C Lim, D Jiang, A Soldan, C Pettigrew, K Oishi… - Alzheimer's & Dementia, 2023