作者
Nan Zhao, Xin Liu, Yongqin Wang, Xiaoqiu Liu, Jiana Li, Litian Yu, Liyuan Ma, Shuyu Wang, Hongye Zhang, Lisheng Liu, Jingbo Zhao, Xingyu Wang
发表日期
2012/12
期刊
Journal of neuroinflammation
卷号
9
页码范围
1-8
出版商
BioMed Central
简介
Background
Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorphisms and their association with ischemic stroke in a Chinese Han population.
Methods
A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes. We tested the genotype-stroke association with logistic regression model.
Results
We found two single nucleotide polymorphisms (SNPs) in CCL11 were associated with ischemic stroke. After adjusting for multiple testing using false discovery rate (FDR) with a 0.20 cut-off point, CCL11 rs4795895 remained statistically …
学术搜索中的文章
N Zhao, X Liu, Y Wang, X Liu, J Li, L Yu, L Ma, S Wang… - Journal of neuroinflammation, 2012